The fixture that holds special places in Liverpool hearts after the events of 2024-25, the Reds do battle Tottenham Hotspur in Sunday's Premier League showdown at Anfield.
The hosts' 5-1 win in this game last season confirmed their status as Premier League champions, and an identical outcome is not beyond the realm of possibility while Spurs sink to even lower lows.
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On April 27, 2025, a merciless Liverpool put five goals past a sorry Spurs side to win English title number 20, Premier League title number two, and Premier League title number one with fans present inside Anfield.
There will be no repeat of the iconic trophy lifts for the Merseyside giants this time around, though, and just when Arne Slot's side were getting back on track in the Champions League race, melancholy was the order of the day at Molineux.
Three straight league wins over Sunderland, Nottingham Forest and West Ham United preceded Liverpool's trip to Wolverhampton Wanderers on March 3, when Andre's last-gasp, deflected winner triggered West Midlands mayhem and left the Reds three points off the top four in the Premier League table.
Slot's side exacted revenge in the FA Cup three days later, but the Dutchman's future inevitably came under the spotlight again when his side were slain 1-0 by Galatasaray in the first leg of their Champions League last-16 tie, making it two losses from three games in all tournaments.
Defeat on Sunday would mark Liverpool's 10th of the Premier League season - not since 2015-16 have they hit double figures in terms of top-flight losses - but it is not outlandish to suggest that Tottenham at home is the friendliest fixture any team can hope for right now.
The statistics back up that suggestion; Tottenham are in the worst form of any Premier League team over the past six gameweeks - taking just one point from a possible 18 - and disaster continues to follow them everywhere they go. Igor Tudor was instilled as the firefighter who could carry his Spurs players out of the burning building, but his fire hose is running on empty, and increasingly disgruntled members of the Lilywhites faithful would be glad to see the back of him.
Just when Tottenham's season seemingly could not hit a lower ebb, the events of Tuesday night occurred; five goals conceded, 17 nightmarish minutes for Antonin Kinsky, and surely a one-way ticket to Champions League elimination.
By overseeing a 5-2 reverse to Atletico Madrid, Tudor suffered the ignominy of becoming the first Tottenham manager to lose each of his first four games in charge, while Spurs also suffered six straight defeats in all competitions for the first time ever.
The 16th-placed Lilywhites are only one point better off than West Ham United and Nottingham Forest in the relegation dogfight, but thanks to their superior goal difference - and the fact that the Irons face Manchester City - they should not end the weekend in the bottom three.
However, that will still come as little comfort to the travelling supporters, whose side have also lost 12 of their last 16 Premier League matches against Liverpool - whether a 13th from 17 will be enough to hand Tudor his P45 remains to be seen.
Prediction: Liverpool 2-0 Tottenham Hotspur
Tottenham's hierarchy and available players have not helped themselves along the way, but the Lilywhites have faced an injury crisis of untold proportions throughout the season, and their stretched squad will almost certainly fall short again.
Some may simply be wondering how many Liverpool will put past their beleaguered visitors, and we expect the Reds to hit the Lilywhites for three this time around.